Understanding genetic factors in recurrent pregnancy loss
Trio Analysis of Recurrent Pregnancy Loss Integrated Bioinformatics Genomics Study (TRIOS)
This study is looking at the genetic reasons behind repeated miscarriages by examining the DNA of couples who have gone through this experience, with the hope of finding clues that could help prevent future losses.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-11059245 on NIH RePORTER |
What this research studies
This research investigates the genetic causes of recurrent pregnancy loss (RPL) by analyzing the genomes of couples who have experienced multiple miscarriages. It aims to identify genetic markers associated with RPL through whole genome sequencing of trios, which include the mother, father, and the pregnancy loss. Additionally, the study will utilize advanced bioinformatics and machine learning techniques to develop predictive algorithms that could help in understanding and potentially mitigating the risk of future miscarriages. By combining genetic data with metabolomic and transcriptomic profiling, the research seeks to provide a comprehensive view of the biological factors contributing to RPL.
Who could benefit from this research
Good fit: Ideal candidates for this research are couples who have experienced recurrent pregnancy loss and are seeking answers regarding the genetic factors involved.
Not a fit: Patients who have not experienced recurrent pregnancy loss or those with known genetic causes of miscarriage may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential interventions for couples experiencing recurrent pregnancy loss.
How similar studies have performed: Other research has shown promise in identifying genetic factors related to pregnancy loss, but this approach is innovative in its comprehensive integration of genomic and bioinformatics techniques.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Lathi, Ruth B — Stanford University
- Study coordinator: Lathi, Ruth B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.