Understanding genetic factors in pulmonary arterial hypertension
Risk stratification in pulmonary arterial hypertension: Intersection of OMICs and longitudinal phenotypes through the PAH Biobank
This study is looking at how our genes might play a role in pulmonary arterial hypertension (PAH) to help us understand the condition better and find ways to tailor treatments for those affected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-10894321 on NIH RePORTER |
What this research studies
This research investigates the genetic underpinnings of pulmonary arterial hypertension (PAH), a serious condition that affects blood flow in the lungs. By analyzing genetic variations in a large cohort of patients, the study aims to identify common genetic factors that contribute to the risk and progression of PAH. Patients will be recruited from a biobank, and their genetic data will be compared to that of healthy controls to uncover potential links between specific genes and the disease. The findings could lead to improved risk stratification and personalized treatment approaches for individuals with PAH.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with pulmonary arterial hypertension, particularly those with idiopathic or heritable forms of the disease.
Not a fit: Patients with pulmonary arterial hypertension caused by other factors unrelated to genetic variations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better identification of patients at risk for severe PAH and more tailored treatment options.
How similar studies have performed: Previous research has shown promising results in identifying genetic factors associated with PAH, suggesting that this approach could yield valuable insights.
Where this research is happening
Cincinnati, United States
- Cincinnati Childrens Hosp Med Ctr — Cincinnati, United States (Active)
Researchers
- Principal investigator: Nichols, William C — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Nichols, William C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.