Understanding genetic factors in psychiatric disorders using advanced genomic techniques
Official title: Dissection of noncoding repeats in psychiatric genetics using synthetic regulatory genomics - Resubmission
Funded at New York University School of Medicine · NIH-11050551 · Data updated 2026-11-12
This study is looking at how certain parts of our DNA might be connected to mental health conditions like schizophrenia and bipolar disorder, and it aims to find new ways to understand and treat these issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | December 1, 2024 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $714,615 |
| NIH project number | 1R01MH136353-01A1 |
| Project ID | NIH-11050551 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with schizophrenia or bipolar disorder, as well as those with a family history of these conditions.
✕Less likely to help
Patients with psychiatric disorders not related to the genetic factors being studied may not benefit from this research.
What this research studies
This research investigates the genetic underpinnings of psychiatric disorders such as schizophrenia and bipolar disorder by focusing on specific noncoding DNA repeats. The team will utilize advanced genomic techniques, including long-read sequencing and synthetic regulatory genomics, to analyze the CACNA1C gene, which is linked to these conditions. By decoding the structure of genetic repeats and their regulatory functions, the research aims to uncover mechanisms that contribute to neuropsychiatric symptoms. This could lead to better understanding and potential new targets for treatment.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and targeted therapies for patients with psychiatric disorders.
How similar studies have gone: Previous research has shown promise in understanding genetic factors in psychiatric disorders, but this approach is innovative and aims to explore previously uncharted areas.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Maurano, Matthew Thomas — New York University School of Medicine
- Study coordinator: Maurano, Matthew Thomas
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.