Understanding genetic factors in nicotine addiction using hybrid rats
Pangenomics of nicotine abuse in the hybrid rat diversity panel
['FUNDING_U01'] · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · NIH-10915406
This study is looking at how our genes might affect how easily people become addicted to nicotine, especially in teens and adults, to help find better ways to treat smoking addiction.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TENNESSEE HEALTH SCI CTR (nih funded) |
| Locations | 1 site (MEMPHIS, UNITED STATES) |
| Trial ID | NIH-10915406 on ClinicalTrials.gov |
What this research studies
This research investigates the genetic variants that contribute to individual differences in nicotine addiction, particularly focusing on adolescents and adults. By utilizing a hybrid rat diversity panel, the study aims to explore how genetic and environmental factors interact to influence smoking behaviors and the risk of relapse. The researchers will collect behavioral data and analyze genetic information to develop a comprehensive understanding of addiction mechanisms, which could lead to more personalized treatment approaches for nicotine dependence.
Who could benefit from this research
Good fit: Ideal candidates for this research include adolescents and adults who are at risk for nicotine addiction or are currently struggling with tobacco use.
Not a fit: Patients who do not use tobacco or have no history of nicotine addiction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective prevention and treatment strategies for nicotine addiction, tailored to individual genetic profiles.
How similar studies have performed: Previous research has shown promise in understanding genetic factors in addiction, but this approach using a hybrid rat model is relatively novel.
Where this research is happening
MEMPHIS, UNITED STATES
- UNIVERSITY OF TENNESSEE HEALTH SCI CTR — MEMPHIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHARP, BURT M — UNIVERSITY OF TENNESSEE HEALTH SCI CTR
- Study coordinator: SHARP, BURT M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.