Understanding genetic factors in nicotine addiction using hybrid rats
Official title: Pangenomics of nicotine abuse in the hybrid rat diversity panel
Funded at University of Tennessee Health Sci Ctr · NIH-10915406 · Data updated 2026-11-12
This study is looking at how our genes might affect how easily people become addicted to nicotine, especially in teens and adults, to help find better ways to treat smoking addiction.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tennessee Health Sci Ctr NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project start | September 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $691,329 |
| NIH project number | 5U01DA057530-02 |
| Project ID | NIH-10915406 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adolescents and adults who are at risk for nicotine addiction or are currently struggling with tobacco use.
✕Less likely to help
Patients who do not use tobacco or have no history of nicotine addiction may not benefit from this research.
What this research studies
This research investigates the genetic variants that contribute to individual differences in nicotine addiction, particularly focusing on adolescents and adults. By utilizing a hybrid rat diversity panel, the study aims to explore how genetic and environmental factors interact to influence smoking behaviors and the risk of relapse. The researchers will collect behavioral data and analyze genetic information to develop a comprehensive understanding of addiction mechanisms, which could lead to more personalized treatment approaches for nicotine dependence.
Why it matters
Potential benefit: If successful, this research could lead to more effective prevention and treatment strategies for nicotine addiction, tailored to individual genetic profiles.
How similar studies have gone: Previous research has shown promise in understanding genetic factors in addiction, but this approach using a hybrid rat model is relatively novel.
Where this research is happening
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University of Tennessee Health Sci Ctr
Memphis, United States Active
Researchers
- Principal investigator: Sharp, Burt M — University of Tennessee Health Sci Ctr
- Study coordinator: Sharp, Burt M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.