Understanding Genetic Factors in Multiple Sclerosis
Deciphering the role of noncoding variation in the pathogenesis of multiple sclerosis
This project aims to understand how genetic differences contribute to multiple sclerosis by looking at specific immune cells from patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-11127511 on NIH RePORTER |
What this research studies
Multiple sclerosis (MS) is a condition affecting the brain and spinal cord, often caused by immune cells mistakenly attacking the body's own myelin. We know that both genes and environment play a part in MS, but it's hard to pinpoint exactly which genetic changes cause the disease. This project uses advanced genetic tools to find specific genetic differences that might be linked to MS. Researchers are focusing on how these genetic changes affect certain immune cells, called T helper cells, which are known to be involved in MS. By studying these cells from MS patients, we hope to learn more about how the disease develops.
Who could benefit from this research
Good fit: This foundational research focuses on understanding the disease at a genetic and cellular level, so it does not directly involve patient recruitment for a clinical trial at this stage.
Not a fit: Patients seeking immediate new treatments or direct clinical interventions would not find direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could help us better understand the genetic roots of multiple sclerosis, potentially leading to new ways to diagnose or treat the condition in the future.
How similar studies have performed: While the specific approach of mapping noncoding variants to target genes in MS patients' T cells is innovative, it builds upon established methods in genomics and immunology.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Ciofani, Maria — Duke University
- Study coordinator: Ciofani, Maria
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.