Understanding genetic factors in mental disorders using advanced algorithms
Official title: Delineating the network effects of mental disorder-associated variants using convex optimization methods
Funded at New York Genome Center · NIH-11093320 · Data updated 2026-11-12
This study is looking at the genes linked to conditions like autism and bipolar disorder to help us understand what makes them happen, which could lead to better treatments for people living with these challenges.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York Genome Center NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 1, 2022 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $773,033 |
| NIH project number | 5R01MH130879-04 |
| Project ID | NIH-11093320 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with autism spectrum disorder or bipolar disorder.
✕Less likely to help
Patients with neuropsychiatric disorders not included in the study's focus may not receive direct benefits from this research.
What this research studies
This research investigates the genetic components associated with neuropsychiatric disorders, such as autism and bipolar disorder, by analyzing large datasets from genome-wide studies. Using advanced mathematical techniques, the researchers aim to identify shared and unique genetic traits that contribute to these conditions. The study employs convex optimization methods to ensure efficient computation and reliable results, which could lead to a better understanding of the biological mechanisms behind these disorders. Patients may benefit from insights that could inform future treatments and interventions.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with neuropsychiatric disorders.
How similar studies have gone: Previous research using similar genetic analysis methods has shown promise in identifying genetic factors related to mental health conditions.
Where this research is happening
-
New York Genome Center
New York, United States Active
Researchers
- Principal investigator: Knowles, David Arthur — New York Genome Center
- Study coordinator: Knowles, David Arthur
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.