Understanding genetic factors in inherited breast and ovarian cancer
Genomic Analysis of Inherited Breast and Ovarian Cancer
This study is looking at the genes of families with a history of breast and ovarian cancer to find hidden changes in DNA that might increase their risk, with the hope of discovering new ways to prevent and treat these cancers.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10940398 on NIH RePORTER |
What this research studies
This research investigates the genetic underpinnings of inherited breast and ovarian cancer by analyzing both coding and non-coding regions of DNA. It aims to identify previously hidden genetic variations that may influence the risk of these cancers in families with a history of the disease. Utilizing advanced genomic technologies such as long-read sequencing and CRISPR, the study will explore how these variations affect gene expression and contribute to cancer risk. By focusing on families with unexplained cancer predisposition, the research seeks to uncover new insights that could lead to better prevention and treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals from families with a strong history of breast and/or ovarian cancer who have not been able to identify causal genetic variants through existing testing.
Not a fit: Patients without a family history of breast or ovarian cancer or those who have already identified causal variants may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved genetic testing and personalized treatment options for individuals at risk of breast and ovarian cancer.
How similar studies have performed: Previous research has successfully identified genetic factors in breast and ovarian cancer, but this study aims to explore novel non-coding variations, making it a potentially groundbreaking approach.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: King, Mary-Claire — University of Washington
- Study coordinator: King, Mary-Claire
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.