Understanding genetic factors in immune system diseases
Official title: Polygenic contributors to disease expressivity in genetic errors of immunity
Funded at Washington University · NIH-11010139 · Data updated 2026-11-12
This study is looking at how your genes might affect the severity of immune system diseases, with the hope of finding better ways to diagnose and treat patients before they experience serious symptoms.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | April 8, 2025 |
| Project end | March 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $413,984 |
| NIH project number | 1P01AI186771-01 |
| Project ID | NIH-11010139 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with genetic errors of immunity, including those with varying degrees of autoimmunity, inflammation, and atopy.
✕Less likely to help
Patients with immune system disorders that are not genetically based or those without a clear genetic component may not benefit from this research.
What this research studies
This research investigates how genetic variations influence the severity and expression of diseases related to the immune system. By analyzing polygenic risk scores and specific genetic variants, the study aims to predict how these factors affect the clinical outcomes of patients with genetic errors of immunity. The approach includes advanced genetic analysis and the exploration of treatment options like precision therapies and stem cell transplantation, which could improve patient management and outcomes. The goal is to enhance early diagnosis and treatment strategies for patients before severe symptoms develop.
Why it matters
Potential benefit: If successful, this research could lead to more accurate predictions of disease severity and better-targeted treatments for patients with immune system disorders.
How similar studies have gone: Previous research has shown promise in using genetic risk factors to predict disease outcomes in similar immune-related conditions, indicating that this approach may yield valuable insights.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Milner, Joshua D. — Washington University
- Study coordinator: Milner, Joshua D.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.