Understanding genetic factors in glaucoma for better eye care
Official title: Clinical and functional assessment of glaucoma-associated mitochondrial gene variants to facilitate precision eye care
Funded at Massachusetts Eye and Ear Infirmary · NIH-10993194 · Data updated 2026-11-12
This study is looking at how certain genes related to energy production in our cells might influence the way primary open-angle glaucoma develops and progresses, so we can find better ways to treat different types of this eye condition for patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts Eye and Ear Infirmary NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | December 1, 2023 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $269,782 |
| NIH project number | 5K23EY035734-02 |
| Project ID | NIH-10993194 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with primary open-angle glaucoma, particularly those with a family history of the disease or known genetic risk factors.
✕Less likely to help
Patients with glaucoma who do not have mitochondrial gene variants or those with other forms of glaucoma unrelated to mitochondrial genetics may not benefit from this research.
What this research studies
This research investigates how specific genetic variants related to mitochondria affect the development and progression of primary open-angle glaucoma (POAG). By analyzing the genetic makeup of patients, the study aims to identify distinct subtypes of glaucoma that may require tailored treatment approaches. The research will involve clinical assessments and genetic testing to better understand the relationship between these variants and the clinical features of glaucoma. Ultimately, the goal is to enhance precision eye care by linking genetic information to patient management strategies.
Why it matters
Potential benefit: If successful, this research could lead to personalized treatment plans for glaucoma patients, improving their outcomes and quality of life.
How similar studies have gone: Previous research has shown promise in using genetic information to inform treatment strategies in other conditions, suggesting potential success for this novel approach in glaucoma.
Where this research is happening
-
Massachusetts Eye and Ear Infirmary
Boston, United States Active
Researchers
- Principal investigator: Aboobakar, Inas F. — Massachusetts Eye and Ear Infirmary
- Study coordinator: Aboobakar, Inas F.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.