Understanding genetic factors in coronary artery disease for children with type 1 diabetes
Examining Susceptibility and Resistance Phenotypes to Enhance Understanding of the Genetic Basis of Major Coronary Artery Disease in Type 1 Diabetes
This study is looking into why kids with type 1 diabetes might be more likely to have heart problems later on, and it hopes to find out if certain genes and immune system responses are involved, so we can discover new ways to help keep their hearts healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10872324 on NIH RePORTER |
What this research studies
This research investigates why children with type 1 diabetes are at a higher risk for developing coronary artery disease compared to others. It aims to identify genetic factors that contribute to this risk and explore how inflammatory and immune response biomarkers may play a role in coronary artery disease. By studying these aspects, the research seeks to uncover new pathways for potential treatments and interventions that could help reduce the risk of heart disease in these patients. The approach includes analyzing genetic variants and biomarkers to better understand their relationship with coronary artery disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are children under 17 years old who have been diagnosed with type 1 diabetes.
Not a fit: Patients who do not have type 1 diabetes or are over 17 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for identifying and treating children with type 1 diabetes at risk for coronary artery disease.
How similar studies have performed: Previous research has shown promising results in identifying genetic factors related to coronary artery disease, but this specific approach focusing on children with type 1 diabetes is relatively novel.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Miller, Rachel Grace — University of Pittsburgh at Pittsburgh
- Study coordinator: Miller, Rachel Grace
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.