Understanding genetic factors in coronary artery disease for children with type 1 diabetes
Official title: Examining Susceptibility and Resistance Phenotypes to Enhance Understanding of the Genetic Basis of Major Coronary Artery Disease in Type 1 Diabetes
Funded at University of Pittsburgh at Pittsburgh · NIH-10872324 · Data updated 2026-11-12
This study is looking into why kids with type 1 diabetes might be more likely to have heart problems later on, and it hopes to find out if certain genes and immune system responses are involved, so we can discover new ways to help keep their hearts healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | July 27, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $403,786 |
| NIH project number | 5R01HL161879-03 |
| Project ID | NIH-10872324 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children under 17 years old who have been diagnosed with type 1 diabetes.
✕Less likely to help
Patients who do not have type 1 diabetes or are over 17 years old may not benefit from this research.
What this research studies
This research investigates why children with type 1 diabetes are at a higher risk for developing coronary artery disease compared to others. It aims to identify genetic factors that contribute to this risk and explore how inflammatory and immune response biomarkers may play a role in coronary artery disease. By studying these aspects, the research seeks to uncover new pathways for potential treatments and interventions that could help reduce the risk of heart disease in these patients. The approach includes analyzing genetic variants and biomarkers to better understand their relationship with coronary artery disease.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for identifying and treating children with type 1 diabetes at risk for coronary artery disease.
How similar studies have gone: Previous research has shown promising results in identifying genetic factors related to coronary artery disease, but this specific approach focusing on children with type 1 diabetes is relatively novel.
Where this research is happening
-
University of Pittsburgh at Pittsburgh
Pittsburgh, United States Active
Researchers
- Principal investigator: Miller, Rachel Grace — University of Pittsburgh at Pittsburgh
- Study coordinator: Miller, Rachel Grace
Related research
Other NIH-funded projects on the same topics.
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Understanding why some people with type 1 diabetes get or avoid major heart disease due to genetics
A study looks at genetic factors and immune-related markers to understand why some young people with type 1 diabetes develop major heart disease and others don’t.
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Why some people with type 1 diabetes get major coronary artery disease and others don't
This project looks for genes and immune-system markers that explain who with type 1 diabetes is likely to develop serious coronary artery disease so risk can be spotted earlier.
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Technological and Educational Approaches to Restore Hypoglycemia Awareness in Type 1 Diabetes
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A randomized trial compares different approaches to help adults with type 1 diabetes recognize when their blood sugar is dipping so they can act quickly.
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Treating impaired hypoglycemia awareness in type 1 diabetes with targeted education and technology
This study tests two treatment approaches to help adults with type 1 diabetes who often don’t realize their blood sugar is getting too low, using a mix of technology and education in two large groups.
-
Helping people with type 1 diabetes regain awareness of dangerous lows
A UK study tests two different approaches to help adults with type 1 diabetes recognize and respond to low blood sugar by comparing a high-tech insulin system with targeted education.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.