Understanding genetic factors in congenital heart disease
Official title: Interpreting coding/non-coding variants for congenital heart disease through gene regulatory networks
Funded at Ut Southwestern Medical Center · NIH-11025634 · Data updated 2026-11-12
This study is looking at how certain genetic differences might affect heart development and lead to congenital heart disease, with the goal of finding better ways to prevent and treat this condition for patients and their families.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | February 1, 2025 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $802,762 |
| NIH project number | 1R01HL176998-01 |
| Project ID | NIH-11025634 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with congenital heart disease or those with a family history of heart defects.
✕Less likely to help
Patients with congenital heart disease caused by known environmental factors or those without a genetic component may not benefit from this research.
What this research studies
This research investigates how genetic variations, particularly in non-coding regions of DNA, contribute to congenital heart disease (CHD). By analyzing gene regulatory networks, the study aims to interpret the effects of these genetic variants on heart development. The researchers will focus on both coding and non-coding variants, utilizing patient-derived data to understand their roles in the dysregulation of cardiac genes. This approach seeks to provide insights into the molecular mechanisms behind CHD, potentially leading to improved prevention and treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and management of congenital heart disease, improving outcomes for affected patients.
How similar studies have gone: Previous research has shown promise in understanding genetic contributions to congenital heart disease through similar approaches, indicating potential for success in this study.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Hon, Gary Chung — Ut Southwestern Medical Center
- Study coordinator: Hon, Gary Chung
Related research
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Multimodal AI to improve genetic diagnosis of congenital heart disease
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Heart development study using patient stem cells to understand NOTCH1 and congenital heart disease
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.