Understanding Genetic Factors in Compulsive Cocaine Use
Identification of Genetic Variants that Contribute to Compulsive Cocaine Intakein Rats
This project looks for genetic differences in animals that might make them more likely to use cocaine compulsively, helping us understand addiction.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11127708 on NIH RePORTER |
What this research studies
Our team is working to find specific genetic changes, brain functions, and physical traits that contribute to addiction-like behaviors, especially compulsive cocaine use. We are using advanced animal models to identify these genetic variations. By creating a special biobank of samples, we are also making it easier for other researchers to study the biological changes that happen with addiction. This work helps build a deeper understanding of why some individuals might be more vulnerable to developing substance use disorders.
Who could benefit from this research
Good fit: This foundational animal research does not directly involve human patients, but future studies building on this work may seek individuals with a history of compulsive cocaine use or those at risk.
Not a fit: Patients not affected by or at risk for cocaine addiction would not directly benefit from this specific line of research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to identify individuals at higher risk for cocaine addiction and develop more targeted treatments.
How similar studies have performed: Previous studies have successfully identified genetic links to various complex behaviors, suggesting this approach has strong potential for uncovering factors in addiction.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: George, Olivier — University of California, San Diego
- Study coordinator: George, Olivier
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.