Understanding genetic factors in cocaine addiction and dopamine function
Official title: Intersecting genetic risk for extreme cocaine self-administration with dopamine neurotransmission
Funded at State University of Ny,binghamton · NIH-11014035 · Data updated 2026-11-12
This study is looking at how genes might play a role in cocaine addiction by observing specially bred mice that can choose to take cocaine, helping us learn more about what makes some people more likely to struggle with this addiction.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of Ny,binghamton NIH-funded |
| Lab location | 1 site (Binghamton, United States) |
| Project start | January 1, 2024 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $248,999 |
| NIH project number | 5R00DA055091-03 |
| Project ID | NIH-11014035 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with a history of cocaine use disorder or those at high genetic risk for addiction.
✕Less likely to help
Patients who do not have a history of cocaine use or are not genetically predisposed to addiction may not benefit from this research.
What this research studies
This research investigates how genetic factors contribute to cocaine addiction by studying voluntary cocaine self-administration in specially bred mice. The researchers aim to identify specific genes and genetic variants that influence the likelihood of developing cocaine use disorder. By examining the effects of these genetic factors on dopamine neurotransmission, a critical brain function affected by cocaine, the study seeks to enhance our understanding of addiction biology. The project will also involve advanced techniques such as fast-scan cyclic voltammetry and optogenetics to explore these relationships.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for individuals struggling with cocaine addiction.
How similar studies have gone: Previous research has shown promise in understanding genetic influences on addiction, suggesting that this approach could yield valuable insights.
Where this research is happening
-
State University of Ny,binghamton
Binghamton, United States Active
Researchers
- Principal investigator: Bagley, Jared R — State University of Ny,binghamton
- Study coordinator: Bagley, Jared R
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.