Understanding genetic factors in blood traits and heart disease
Official title: Scalable multi-ancestry functional genomics of blood traits and cardiovascular disease
Funded at New York Genome Center · NIH-10803320 · Data updated 2026-11-12
This study is looking at how certain genes might affect heart disease and blood traits, using cutting-edge technology to help us understand these connections better, so we can find new ways to help people at risk for cardiovascular issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York Genome Center NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | July 15, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $827,665 |
| NIH project number | 1R01HL168247-01A1 |
| Project ID | NIH-10803320 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a family history of cardiovascular disease or those who have been diagnosed with blood-related conditions.
✕Less likely to help
Patients without any genetic predisposition to cardiovascular disease or those who do not have blood-related health issues may not benefit from this research.
What this research studies
This research investigates the genetic variants linked to cardiovascular disease (CVD) and blood traits by utilizing advanced genomic techniques. It aims to identify the causal genetic variants and the specific cell types affected by these variants, particularly focusing on blood-related mechanisms. The study employs scalable methods to enhance the discovery of genetic factors across diverse populations, which could lead to a better understanding of how these variants influence disease. By leveraging CRISPR technology and phenotypic assays, the research seeks to connect genetic variants to their functional roles in CVD.
Why it matters
Potential benefit: If successful, this research could lead to improved identification of genetic risk factors for cardiovascular disease, enabling more personalized prevention and treatment strategies for patients.
How similar studies have gone: Previous research utilizing genome-wide association studies has shown success in identifying genetic variants associated with various diseases, suggesting that this approach has the potential for significant breakthroughs in understanding cardiovascular disease.
Where this research is happening
-
New York Genome Center
New York, United States Active
Researchers
- Principal investigator: Sanjana, Neville — New York Genome Center
- Study coordinator: Sanjana, Neville
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.