Understanding genetic factors in autoimmune diseases
Official title: Methods and tools to integrate multi-omics datasets to understand preclinical autoimmune and immune-mediated diseases
Funded at Pennsylvania State Univ Hershey Med Ctr · NIH-11132900 · Data updated 2026-11-12
This study is looking at how our genes might play a role in the early signs of autoimmune diseases, so we can find better ways to spot these conditions early and help people who are at risk.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pennsylvania State Univ Hershey Med Ctr NIH-funded |
| Lab location | 1 site (Hershey, United States) |
| Project start | July 5, 2024 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $443,830 |
| NIH project number | 5U01AI185638-02 |
| Project ID | NIH-11132900 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals experiencing early or preclinical symptoms of autoimmune diseases such as lupus, psoriasis, or Sjogren's disease.
✕Less likely to help
Patients with well-established autoimmune diseases who are already receiving treatment may not benefit directly from this research.
What this research studies
This research focuses on identifying genetic factors that contribute to the early stages of autoimmune and immune-mediated diseases. By developing new methods and software tools, the project aims to analyze multi-omics datasets to detect genetic associations and understand how these factors influence the progression from preclinical symptoms to full-blown disease. This approach will help in recognizing early signs of autoimmune conditions, which can be challenging due to non-specific symptoms. The findings could lead to improved diagnostic techniques and targeted interventions for patients at risk.
Why it matters
Potential benefit: If successful, this research could lead to earlier and more accurate diagnoses of autoimmune diseases, potentially improving treatment outcomes.
How similar studies have gone: Previous research has shown promise in using genetic analysis to understand autoimmune diseases, indicating that this approach could yield valuable insights.
Where this research is happening
-
Pennsylvania State Univ Hershey Med Ctr
Hershey, United States Active
Researchers
- Principal investigator: Liu, Dajiang — Pennsylvania State Univ Hershey Med Ctr
- Study coordinator: Liu, Dajiang
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.