Understanding genetic factors in Alzheimer's disease through advanced statistical models
Estimation and inference in directed acyclic graphical models for biological networks
This study is looking at how our genes might play a role in developing Alzheimer's disease, with the hope of finding better ways to treat it based on individual genetic information.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-11011340 on NIH RePORTER |
What this research studies
This research focuses on identifying how genetic variants influence the development of Alzheimer's disease by using advanced statistical and computational methods. It aims to unravel the complex relationships between genes and their regulatory roles, particularly in the context of high-dimensional genomic data. By developing new tools for estimating and inferring gene regulatory networks, the project seeks to pinpoint causal genetic factors that contribute to Alzheimer's and other neurodegenerative diseases. Patients may benefit from insights that could lead to more targeted treatment strategies based on their genetic profiles.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of Alzheimer's disease or those who are genetically predisposed to the condition.
Not a fit: Patients without any genetic risk factors for Alzheimer's disease or those who do not have a diagnosis of neurodegenerative diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for Alzheimer's disease based on genetic insights.
How similar studies have performed: Previous research has shown promise in using similar statistical approaches to uncover genetic factors in complex diseases, indicating a potential for success in this area.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Shen, Xiaotong Tom — University of Minnesota
- Study coordinator: Shen, Xiaotong Tom
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.