Understanding genetic factors in Alzheimer's disease risk and resilience
Genetic and single-cell multi-omic characterization of Alzheimer's disease risk and resilience pathways
This study is looking at how our genes and brain chemistry affect the risk of Alzheimer's disease, and it’s for anyone interested in understanding more about the condition and how things like diet might help lower that risk.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10865795 on NIH RePORTER |
What this research studies
This research investigates the genetic and molecular factors that contribute to the risk and resilience of Alzheimer's disease (AD). By analyzing brain tissue from both healthy individuals and those with AD, the study aims to identify specific genes and pathways that influence the disease. It also explores how interventions like caloric restriction may help mitigate AD risk. The research employs advanced techniques to perform detailed molecular profiling, which could lead to new insights into preventing or treating AD.
Who could benefit from this research
Good fit: Ideal candidates for this research include older adults, particularly those aged 65 and above, who may be at risk for Alzheimer's disease or are cognitively healthy centenarians.
Not a fit: Patients who are younger than 65 or those with advanced Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of targeted therapies that reduce the risk of Alzheimer's disease or enhance resilience against it.
How similar studies have performed: Previous research has shown promise in understanding genetic factors related to Alzheimer's disease, making this approach both relevant and potentially impactful.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: D'oliveira Albanus, Ricardo — Washington University
- Study coordinator: D'oliveira Albanus, Ricardo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.