Understanding genetic factors in Alzheimer's disease risk and resilience
Official title: Genetic and single-cell multi-omic characterization of Alzheimer's disease risk and resilience pathways
Funded at Washington University · NIH-10865795 · Data updated 2026-11-12
This study is looking at how our genes and brain chemistry affect the risk of Alzheimer's disease, and it’s for anyone interested in understanding more about the condition and how things like diet might help lower that risk.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | July 15, 2024 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $125,896 |
| NIH project number | 1K99AG086583-01 |
| Project ID | NIH-10865795 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include older adults, particularly those aged 65 and above, who may be at risk for Alzheimer's disease or are cognitively healthy centenarians.
✕Less likely to help
Patients who are younger than 65 or those with advanced Alzheimer's disease may not benefit from this research.
What this research studies
This research investigates the genetic and molecular factors that contribute to the risk and resilience of Alzheimer's disease (AD). By analyzing brain tissue from both healthy individuals and those with AD, the study aims to identify specific genes and pathways that influence the disease. It also explores how interventions like caloric restriction may help mitigate AD risk. The research employs advanced techniques to perform detailed molecular profiling, which could lead to new insights into preventing or treating AD.
Why it matters
Potential benefit: If successful, this research could lead to the development of targeted therapies that reduce the risk of Alzheimer's disease or enhance resilience against it.
How similar studies have gone: Previous research has shown promise in understanding genetic factors related to Alzheimer's disease, making this approach both relevant and potentially impactful.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: D'oliveira Albanus, Ricardo — Washington University
- Study coordinator: D'oliveira Albanus, Ricardo
Related research
Other NIH-funded projects on the same topics.
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Genetic and single-cell study of Alzheimer’s risk and resilience
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Why some brains resist or cope with Alzheimer's
Researchers use brain scans and long-term health records to find why some older adults avoid or cope better with Alzheimer's changes.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.