Understanding genetic factors in Alzheimer's disease among older adults in India
Harmonized Diagnostic Assessment of Dementia (DAD) for Longitudinal Aging Study of India (LASI)-Genomic study.
This study is looking at how our genes might affect the risk of Alzheimer's disease and memory changes as we age, specifically in older adults from India, and it involves analyzing the DNA of 2,400 people to better understand these connections.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project ID | NIH-10685990 on NIH RePORTER |
What this research studies
This research investigates the genetic factors that contribute to Alzheimer's disease and cognitive aging in older adults, specifically focusing on the Indian population. By sequencing the DNA of 2,400 individuals from various regions in India, the study aims to uncover the genetic mutations associated with dementia risk. Participants will be drawn from the Longitudinal Aging Study of India, which includes a diverse sample of older adults aged 45 and above. The findings could help clarify how genetics and lifestyle interact in the development of Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults aged 45 and above, particularly those with a family history of dementia or cognitive decline.
Not a fit: Patients who are younger than 45 or do not have any cognitive issues or family history of dementia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potentially new strategies for preventing or treating Alzheimer's disease in older adults.
How similar studies have performed: Previous research has shown success in understanding genetic factors in Alzheimer's disease in other populations, but this study is novel as it focuses specifically on the underrepresented Indian population.
Where this research is happening
Los Angeles, UNITED STATES
- University of Southern California — Los Angeles, United States (Active)
Researchers
- Principal investigator: Lee, Jinkook — University of Southern California
- Study coordinator: Lee, Jinkook
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.