Understanding genetic factors in alcohol use disorder across different species
A Framework for Translating Polygenic Findings Related to Alcohol Use Disorder Across Species
This study is looking at how genes linked to alcohol use disorder in people can help us understand similar issues in rodents, using a new method to combine genetic information, which could lead to better treatments for those struggling with alcohol problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10909932 on NIH RePORTER |
What this research studies
This research investigates how genetic findings related to alcohol use disorder (AUD) can be translated between humans and rodents. By developing a new framework called polygenic transcriptomic risk scores (PTRS), the study aims to sum the effects of gene expression rather than individual genetic variations, allowing for better comparisons across species. This approach could enhance our understanding of AUD and its underlying genetic mechanisms, potentially leading to improved treatment strategies. The research will assess the predictive power of PTRS in relation to behaviors associated with AUD in rodents, based on human genetic data.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of alcohol use disorder or those at risk due to genetic factors.
Not a fit: Patients who do not have a history of alcohol use disorder or related genetic predispositions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for individuals suffering from alcohol use disorder.
How similar studies have performed: While the integration of genetic findings across species is a novel approach, similar methodologies have shown promise in other areas of psychiatric research.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Palmer, Abraham a — University of California, San Diego
- Study coordinator: Palmer, Abraham a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.