Understanding genetic factors in age-related macular degeneration
Connecting AMD SNPs to Functions Using Allele-specific Interactions
['FUNDING_R01'] · JOHNS HOPKINS UNIVERSITY · NIH-11009557
This study is looking at how certain genes might affect the risk of developing age-related macular degeneration (AMD), which can cause vision loss in older adults, to help find better ways to treat the condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-11009557 on ClinicalTrials.gov |
What this research studies
This research investigates the genetic underpinnings of age-related macular degeneration (AMD), a leading cause of vision loss in older adults. By examining specific genetic variations known as single nucleotide polymorphisms (SNPs), the study aims to uncover how these genetic factors influence the risk of developing AMD. The researchers will utilize advanced techniques such as genomewide association studies and chromatin immunoprecipitation sequencing to identify the interactions between these SNPs and proteins that may affect gene expression related to AMD. This comprehensive approach could lead to a better understanding of the disease mechanisms and pave the way for new treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who are at risk for or have been diagnosed with age-related macular degeneration.
Not a fit: Patients with other forms of vision loss unrelated to age-related macular degeneration may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective treatments for age-related macular degeneration, particularly for its atrophic form.
How similar studies have performed: Previous research has shown promise in understanding genetic factors in AMD, indicating that this approach could yield valuable insights.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZACK, DONALD J. — JOHNS HOPKINS UNIVERSITY
- Study coordinator: ZACK, DONALD J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: age related macular disease