Understanding genetic factors in addiction across species
Building Bridges to Allow Cross-species Translational genetics for the Study of Addiction
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA, SAN DIEGO · NIH-10909173
This study is looking at how our genes might influence addiction by comparing human genetic information with studies in animals, and it hopes to find new ways to help people struggling with addiction.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN DIEGO (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-10909173 on ClinicalTrials.gov |
What this research studies
This research investigates the genetic basis of addiction by integrating human genetic data with studies in model organisms. It aims to develop a new framework for cross-species translation of polygenic risk scores, which predict the risk of addiction traits based on numerous genetic variants. By using transcriptomic analyses, the research seeks to identify how human genomic variations influence addiction and could lead to new therapeutic approaches. This innovative methodology addresses the challenges of translating genetic findings from humans to other species.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of substance use disorders, including those affected by alcohol, tobacco, cannabis, or opioids.
Not a fit: Patients who do not have a history of substance use disorders or genetic predispositions to addiction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for addiction by providing deeper insights into its genetic underpinnings.
How similar studies have performed: Other research has shown promise in using genetic insights to understand addiction, but this approach of cross-species polygenic translation is relatively novel.
Where this research is happening
LA JOLLA, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN DIEGO — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SANCHEZ ROIGE, SANDRA — UNIVERSITY OF CALIFORNIA, SAN DIEGO
- Study coordinator: SANCHEZ ROIGE, SANDRA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.