Understanding genetic factors behind high blood pressure in Black Americans
Genetic Causes of Endocrine Hypertension in Black Americans
This study is looking into the genetic reasons behind primary aldosteronism, a condition that causes high blood pressure, especially in Black Americans, to help find better ways to diagnose and treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-11167599 on NIH RePORTER |
What this research studies
This research investigates the genetic causes of primary aldosteronism (PA), a common adrenal disorder leading to high blood pressure, particularly in Black Americans. By utilizing next-generation sequencing, the study aims to identify specific genetic mutations that contribute to increased aldosterone production and hypertension. The research focuses on understanding how disruptions in calcium homeostasis in adrenal cells can lead to this condition, which is often under-recognized and untreated in affected populations. The findings could help improve diagnosis and treatment options for patients suffering from this condition.
Who could benefit from this research
Good fit: Ideal candidates for this research include Black Americans who have been diagnosed with hypertension, particularly those suspected of having primary aldosteronism.
Not a fit: Patients who do not identify as Black Americans or those without hypertension may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better identification and treatment of high blood pressure caused by primary aldosteronism in Black Americans.
How similar studies have performed: Previous research has shown success in identifying genetic mutations related to primary aldosteronism, but this specific focus on Black Americans is relatively novel.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Rege, Juilee — University of Michigan at Ann Arbor
- Study coordinator: Rege, Juilee
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.