Understanding genetic factors behind congenital heart defects
Official title: Random Field Methods for integrative genomic analysis and high-dimensional risk prediction of congenital heart defects
Funded at Trustees of Indiana University · NIH-10905156 · Data updated 2026-11-12
This study is looking at how genes and the environment can cause congenital heart defects, which are the most common birth defects, to help find better ways to prevent and treat them for families affected by these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Trustees of Indiana University NIH-funded |
| Lab location | 1 site (Bloomington, United States) |
| Project start | September 8, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $487,567 |
| NIH project number | 1R56HL164477-01A1 |
| Project ID | NIH-10905156 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include children diagnosed with congenital heart defects and their families.
✕Less likely to help
Patients with congenital heart defects caused solely by non-genetic factors may not benefit from this research.
What this research studies
This research investigates the genetic and environmental factors contributing to congenital heart defects (CHDs), which are the most common type of birth defect. By analyzing genetic data from large-scale studies and biobanks, the project aims to uncover the complex interactions that lead to CHDs. The research will utilize samples from various federal resources to improve risk prediction models and enhance understanding of the disease's etiology. Patients may benefit from insights that could lead to better prevention and treatment strategies for CHDs.
Why it matters
Potential benefit: If successful, this research could lead to improved risk prediction and prevention strategies for congenital heart defects in children.
How similar studies have gone: Previous research has shown promise in understanding genetic contributions to congenital conditions, suggesting potential for success in this integrative approach.
Where this research is happening
-
Trustees of Indiana University
Bloomington, United States Active
Researchers
- Principal investigator: Li, Ming — Trustees of Indiana University
- Study coordinator: Li, Ming
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.