Understanding genetic factors affecting treatment outcomes in childhood leukemia
Characterizing noncoding GWAS variants in acute lymphoblastic leukemia treatment outcome
This study is looking at how certain genetic differences can affect how well children with acute lymphoblastic leukemia respond to treatment, with the goal of finding ways to tailor therapies to help them do better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Jude Children's Research Hospital NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project ID | NIH-10670131 on NIH RePORTER |
What this research studies
This research investigates how genetic variations, particularly noncoding variants, influence the treatment outcomes of pediatric acute lymphoblastic leukemia (ALL). By analyzing genomic data from over 40 ALL samples, the study aims to create detailed maps of the ALL genome, identifying regulatory elements that may contribute to drug resistance. The researchers will integrate these findings with clinical data from patients to better understand the mechanisms behind treatment failure and relapse. This approach could lead to more personalized treatment strategies for children with ALL.
Who could benefit from this research
Good fit: Ideal candidates for this research are children diagnosed with acute lymphoblastic leukemia, particularly those who have experienced treatment resistance or relapse.
Not a fit: Patients with other types of leukemia or those who are not diagnosed with acute lymphoblastic leukemia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could improve treatment strategies and outcomes for children with acute lymphoblastic leukemia by identifying genetic factors that influence drug resistance.
How similar studies have performed: Previous studies have shown success in using genomic mapping to identify factors influencing treatment outcomes in various cancers, suggesting that this approach may yield valuable insights for pediatric ALL as well.
Where this research is happening
Memphis, United States
- St. Jude Children's Research Hospital — Memphis, United States (Active)
Researchers
- Principal investigator: Savic, Daniel — St. Jude Children's Research Hospital
- Study coordinator: Savic, Daniel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.