Understanding genetic factors affecting lymphoma outcomes in African Americans
Official title: Genetic Origins of Adverse Outcomes in African Americans with Lymphoma
Funded at Duke University · NIH-11086606 · Data updated 2026-11-12
This study is looking at the genetic differences in tumors from African American patients with diffuse large B cell lymphoma, a type of blood cancer, to understand why they may have worse health outcomes than Caucasian patients, and it hopes to find ways to create better treatments for everyone affected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | April 18, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $485,691 |
| NIH project number | 5R01CA271589-03 |
| Project ID | NIH-11086606 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are African American individuals diagnosed with diffuse large B cell lymphoma.
✕Less likely to help
Patients with lymphoma who are not of African American descent may not benefit directly from this research.
What this research studies
This research investigates the genetic differences in tumors of African American patients with diffuse large B cell lymphoma (DLBCL), a common type of blood cancer. It aims to identify specific genetic mutations that contribute to poorer health outcomes compared to Caucasian patients, even after accounting for socioeconomic factors and access to care. By analyzing both tumor and germline genetics, the study seeks to uncover the underlying causes of these disparities and characterize the functional impact of identified genetic alterations. This comprehensive approach could lead to better-targeted treatments for affected individuals.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies and outcomes for African American patients with lymphoma.
How similar studies have gone: Previous research has indicated genetic differences in cancer outcomes among diverse populations, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Dave, Sandeep — Duke University
- Study coordinator: Dave, Sandeep
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.