Understanding genetic factors affecting hearing loss treatment outcomes
Spiral Ganglion Health: from Genomics to Gene Therapy
This study is looking at how certain genes might affect how well cochlear implants work for kids with hearing loss from birth, so doctors can better understand who might need extra support before and after the surgery.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11099686 on NIH RePORTER |
What this research studies
This research investigates the genetic factors that influence the effectiveness of cochlear implants in children with congenital hearing loss. By identifying specific genetic variations that impact the health of spiral ganglion neurons, the study aims to predict which patients may have poor outcomes from cochlear implantation. The approach includes analyzing genetic data alongside clinical factors to improve pre-operative counseling and post-operative care for affected individuals. Ultimately, the goal is to enhance treatment strategies for children with hearing loss.
Who could benefit from this research
Good fit: Ideal candidates for this research include children with congenital hearing loss who are potential candidates for cochlear implantation.
Not a fit: Patients with hearing loss not eligible for cochlear implantation or those with other unrelated auditory conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved outcomes for children receiving cochlear implants by tailoring treatments based on genetic profiles.
How similar studies have performed: Previous research has shown promising results in using genetic information to predict treatment outcomes in similar contexts, indicating a potential for success in this approach.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Shearer, Aiden Eliot — Boston Children's Hospital
- Study coordinator: Shearer, Aiden Eliot
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.