Understanding genetic factors affecting cholesterol levels in diverse populations
Whole genome sequences in ethnically diverse individuals to comprehensively characterize the genetic mechanisms of dyslipidemias
This study is looking at how our genes affect cholesterol and fat levels in the blood, which can help us find new ways to manage heart health for people with high lipid levels.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10978305 on NIH RePORTER |
What this research studies
This research investigates the genetic mechanisms behind dyslipidemias, which are abnormal lipid levels that can lead to heart disease. By utilizing whole genome sequencing from approximately 600,000 ethnically diverse individuals, the study aims to identify novel genetic variations that influence plasma lipid levels. The approach combines genomic data with bioinformatics to better understand how these variations affect cholesterol and other lipids in the blood. This comprehensive analysis will help in developing personalized strategies for managing lipid-related health risks.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals from diverse ethnic backgrounds who have abnormal lipid levels or a family history of dyslipidemias.
Not a fit: Patients who do not have any lipid abnormalities or genetic predispositions to dyslipidemias may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of cholesterol levels, potentially reducing the risk of coronary heart disease for many individuals.
How similar studies have performed: Previous research has shown success in using whole genome sequencing to identify genetic factors related to various health conditions, suggesting that this approach could yield valuable insights in this area as well.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Natarajan, Pradeep — Massachusetts General Hospital
- Study coordinator: Natarajan, Pradeep
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.