Understanding genetic factors affecting cancer treatment responses
Official title: Administrative Core
Funded at Wayne State University · NIH-10879548 · Data updated 2026-11-12
This study is looking at how your genetic background might affect how well a certain cancer treatment works, especially for people with HER2-positive cancer, so that doctors can create more personalized and effective therapies for different racial groups.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wayne State University NIH-funded |
| Lab location | 1 site (Detroit, United States) |
| Project start | September 5, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $107,484 |
| NIH project number | 1P20CA290450-01 |
| Project ID | NIH-10879548 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with HER2-positive cancers who belong to diverse racial and ethnic backgrounds.
✕Less likely to help
Patients with cancers that are not HER2-positive or those who do not have a genetic component influencing their treatment response may not benefit from this research.
What this research studies
This research investigates how genetic differences related to ancestry may influence the effectiveness of anti-HER2 antibody therapy in cancer treatment. It aims to identify specific genetic regulators that affect macrophage function and response to this therapy, which could explain why certain racial groups respond differently. The project also focuses on creating a strong infrastructure to support collaborations in immuno-oncology and health disparities research, ensuring effective communication and management among researchers. Patients may benefit from insights that lead to more personalized and effective cancer treatments based on their genetic background.
Why it matters
Potential benefit: If successful, this research could lead to more tailored cancer therapies that improve treatment outcomes for diverse patient populations.
How similar studies have gone: Previous research has shown promising results in understanding genetic factors influencing treatment responses, indicating that this approach has potential for success.
Where this research is happening
-
Wayne State University
Detroit, United States Active
Researchers
- Principal investigator: Schwartz, Ann G. — Wayne State University
- Study coordinator: Schwartz, Ann G.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.