Understanding genetic factors affecting Alzheimer's in individuals with Down syndrome
Project 2: Genetic Contributions to AD in DS
This study is looking at how genes might affect memory and thinking changes in people with Down syndrome, especially as they get older and face risks like Alzheimer's disease, to help doctors provide better care tailored to each person's needs.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10667602 on NIH RePORTER |
What this research studies
This research aims to identify and analyze genetic factors that influence the varying degrees of cognitive decline in individuals with Down syndrome (DS), particularly focusing on Alzheimer's disease. By examining different stages of cognitive impairment—from unaffected to mild cognitive impairment and dementia—the study seeks to establish clear clinical subtypes and their progression. Utilizing advanced blood and cerebrospinal fluid biomarkers, along with non-invasive imaging techniques, the research will help define molecular signatures linked to dementia risk. This approach aims to enhance precision medicine for individuals with DS, ultimately improving their care and outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults with Down syndrome, particularly those showing early signs of cognitive decline or at risk for Alzheimer's disease.
Not a fit: Patients without Down syndrome or those who are not at risk for Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better risk assessment and personalized treatment strategies for individuals with Down syndrome at risk of Alzheimer's disease.
How similar studies have performed: Previous research has shown promise in identifying genetic factors related to Alzheimer's disease, suggesting that this approach could yield valuable insights.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Lee, Joseph Hyungwoo — University of Pittsburgh at Pittsburgh
- Study coordinator: Lee, Joseph Hyungwoo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.