Understanding genetic errors that affect the immune system
Official title: Novel Mechanisms of Genetic Errors of Immunity
Funded at Washington University · NIH-11010133 · Data updated 2026-11-12
This study is looking into genetic immune system disorders to find new ways to diagnose and treat people who struggle with issues like autoimmunity and inflammation.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | April 8, 2025 |
| Project end | March 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $2,483,910 |
| NIH project number | 1P01AI186771-01 |
| Project ID | NIH-11010133 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Inborn Errors of Immunity or related immune dysregulation disorders.
✕Less likely to help
Patients with immune disorders not related to genetic errors or those with purely environmental causes may not benefit from this research.
What this research studies
This research investigates Inborn Errors of Immunity (IEI), which include over 500 genetic disorders impacting the immune system. It focuses on Primary Immune Regulation Disorders (PIRD) that lead to issues like autoimmunity and inflammation. The team aims to uncover novel genetic mechanisms, including epigenetic factors and somatic mutations, that contribute to these disorders. By mapping genes and understanding their expression patterns, the research seeks to improve diagnostic rates and treatment options for affected patients.
Why it matters
Potential benefit: If successful, this research could lead to better diagnosis and treatment strategies for patients with immune system disorders.
How similar studies have gone: Previous research has shown promise in understanding genetic mechanisms of immune disorders, suggesting potential for breakthroughs in this area.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Cooper, Megan Anne — Washington University
- Study coordinator: Cooper, Megan Anne
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.