Understanding genetic diversity in bacteria causing bloodstream infections
Official title: Within-host diversity of Gram negative bacteria from bloodstream infections
Funded at University of Pittsburgh at Pittsburgh · NIH-10991019 · Data updated 2026-11-12
This study is looking at how different types of Klebsiella pneumoniae bacteria, which can cause serious infections in the blood, behave in the gut and how their genetic differences might affect how well antibiotics work, helping doctors find better ways to treat these infections for patients.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | November 21, 2023 |
| Project end | October 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $205,990 |
| NIH project number | 5R21AI176369-02 |
| Project ID | NIH-10991019 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients experiencing bloodstream infections caused by Klebsiella pneumoniae, particularly those with a history of antibiotic use.
✕Less likely to help
Patients with infections caused by bacteria other than Klebsiella pneumoniae may not benefit from this research.
What this research studies
This research investigates how genetically diverse strains of Klebsiella pneumoniae, a bacterium that can cause serious bloodstream infections, develop within the gastrointestinal tract. By using advanced whole genome sequencing techniques, the study aims to identify the genetic variations among these strains and their implications for antibiotic resistance and treatment outcomes. Patients with bloodstream infections may have different strains that respond differently to antibiotics, which this research seeks to clarify. The findings could lead to improved diagnostic and treatment strategies for infections caused by these bacteria.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for bloodstream infections caused by antibiotic-resistant bacteria.
How similar studies have gone: Previous research has shown that understanding genetic diversity in bacteria can lead to significant advancements in treatment strategies, indicating potential success for this approach.
Where this research is happening
-
University of Pittsburgh at Pittsburgh
Pittsburgh, United States Active
Researchers
- Principal investigator: Nguyen, M. Hong Thi — University of Pittsburgh at Pittsburgh
- Study coordinator: Nguyen, M. Hong Thi
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.