Understanding genetic disorders affecting brain development
Modeling Reciprocal Genomic Disorders in Neuronal Cells and Cerebral Organoids
This study is looking at how certain genetic changes can affect brain development and contribute to conditions like autism and ADHD, using advanced lab techniques, and it hopes to find new ways to help people with these disorders.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-11195793 on NIH RePORTER |
What this research studies
This research focuses on investigating how specific genetic mutations contribute to neurodevelopmental disorders by using advanced techniques such as stem cells and organoids. The principal investigator, Dr. Xander Nuttle, aims to model reciprocal genomic disorders in neuronal cells to better understand the underlying mechanisms of conditions like autism and ADHD. By combining experimental and computational methods, the research seeks to identify how these genetic changes affect brain function and development. Patients may benefit from insights gained that could lead to new treatment strategies for these disorders.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals diagnosed with autism spectrum disorder or attention deficit hyperactivity disorder.
Not a fit: Patients with neurodevelopmental disorders not linked to the specific genetic mutations being studied may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for neurodevelopmental disorders such as autism and ADHD.
How similar studies have performed: Previous research has shown promise in using similar genomic and cellular modeling approaches to understand neurodevelopmental disorders, indicating a potential for success in this area.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Nuttle, Xander — University of Michigan at Ann Arbor
- Study coordinator: Nuttle, Xander
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.