Understanding genetic differences in the pathogen Cryptococcus neoformans
Official title: Deciphering the significance of pathogen genetic variation and evolution
Funded at University of California, San Francisco · NIH-11134635 · Data updated 2026-11-12
This study is looking at how different genes in a type of yeast called Cryptococcus neoformans affect how it behaves and responds to treatments, which could help create better therapies for people dealing with infections caused by this yeast.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | July 8, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $690,558 |
| NIH project number | 5R01AI185204-02 |
| Project ID | NIH-11134635 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with infections caused by Cryptococcus neoformans or those at risk of such infections.
✕Less likely to help
Patients with infections caused by other pathogens unrelated to Cryptococcus neoformans may not benefit from this research.
What this research studies
This research investigates how genetic variations in the yeast Cryptococcus neoformans affect its behavior and response to treatments. By using advanced genetic techniques and mouse models, the team aims to uncover how different genetic backgrounds influence the pathogen's ability to survive and cause disease. This knowledge could lead to the development of more effective therapies tailored to various strains of the pathogen, ultimately improving patient outcomes.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for infections caused by Cryptococcus neoformans.
How similar studies have gone: Previous research has shown promise in understanding genetic variations in pathogens, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Madhani, Hiten D — University of California, San Francisco
- Study coordinator: Madhani, Hiten D
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.