Understanding genetic differences in the pathogen Cryptococcus neoformans
Deciphering the significance of pathogen genetic variation and evolution
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-11134635
This study is looking at how different genes in a type of yeast called Cryptococcus neoformans affect how it behaves and responds to treatments, which could help create better therapies for people dealing with infections caused by this yeast.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-11134635 on ClinicalTrials.gov |
What this research studies
This research investigates how genetic variations in the yeast Cryptococcus neoformans affect its behavior and response to treatments. By using advanced genetic techniques and mouse models, the team aims to uncover how different genetic backgrounds influence the pathogen's ability to survive and cause disease. This knowledge could lead to the development of more effective therapies tailored to various strains of the pathogen, ultimately improving patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with infections caused by Cryptococcus neoformans or those at risk of such infections.
Not a fit: Patients with infections caused by other pathogens unrelated to Cryptococcus neoformans may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for infections caused by Cryptococcus neoformans.
How similar studies have performed: Previous research has shown promise in understanding genetic variations in pathogens, suggesting that this approach could yield valuable insights.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MADHANI, HITEN D — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: MADHANI, HITEN D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.