Understanding Genetic Differences in Substance Use Disorders
Functional genetic variants in substance use disorders
This project looks for genetic differences that might make people more likely to develop substance use disorders.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-11123299 on NIH RePORTER |
What this research studies
This project aims to uncover specific genetic changes that contribute to substance use disorders (SUDs). Researchers are creating new laboratory methods and computer models to find out how these genetic differences affect gene activity, especially in brain cells like neurons and astrocytes. By studying tens of thousands of genetic variations, they hope to understand the underlying biological reasons for SUDs. This work combines new data with existing genetic information to build a clearer picture of these complex conditions.
Who could benefit from this research
Good fit: This foundational genetic research does not directly involve patient participation, but future studies building on this work might seek individuals with substance use disorders or specific genetic profiles.
Not a fit: Patients seeking immediate new treatments or direct clinical intervention will not find direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to a better understanding of the biological causes of substance use disorders, potentially guiding the development of new prevention strategies or treatments.
How similar studies have performed: This project builds upon previous studies on genomic variation and gene regulation, suggesting a foundation of existing knowledge in the field.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Edenberg, Howard J — Indiana University Indianapolis
- Study coordinator: Edenberg, Howard J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.