Understanding Genetic Differences in Inflammatory Bowel Disease
Functional outcomes of inflammatory bowel disease associated variants
This research explores how tiny genetic differences in people with inflammatory bowel disease affect their body's immune responses to microbes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11141756 on NIH RePORTER |
What this research studies
Our bodies have natural defenses against microbes, and in inflammatory bowel disease (IBD), these defenses can sometimes go awry. This project looks closely at specific genetic variations linked to IBD to understand how they change the body's immune system. We want to see how these genetic differences impact the way immune cells respond to bacteria and produce important signaling molecules. By understanding these functional changes, we hope to better categorize individuals and uncover the core mechanisms driving IBD.
Who could benefit from this research
Good fit: This foundational research is for patients with inflammatory bowel disease who are interested in how genetic factors influence their condition.
Not a fit: Patients without inflammatory bowel disease or those not interested in the genetic underpinnings of the condition may not find direct benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to a clearer understanding of why some people develop inflammatory bowel disease and help identify new targets for personalized treatments.
How similar studies have performed: While many genetic links to IBD have been found, the specific functional consequences of most of these genetic variations are still largely unknown, making this a novel area of focus.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Abraham, Clara — Yale University
- Study coordinator: Abraham, Clara
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.