Understanding Genetic Differences in Brain Disorders
Systematic Functional Interpretation of Regulatory Variants in Neuropsychiatric Disorders
['FUNDING_R01'] · ENDEAVOR HEALTH CLINICAL OPERATIONS · NIH-11010034
This work looks at how tiny genetic changes in brain cells might contribute to conditions like schizophrenia and other mental health challenges.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ENDEAVOR HEALTH CLINICAL OPERATIONS (nih funded) |
| Locations | 1 site (EVANSTON, UNITED STATES) |
| Trial ID | NIH-11010034 on ClinicalTrials.gov |
What this research studies
Many genetic differences linked to brain disorders are found in parts of our DNA that don't directly make proteins, making their role hard to understand. This project uses special human brain cells grown in the lab, called induced pluripotent stem cell (hiPSC) neurons, to see how these genetic differences change how DNA is organized and how genes are turned on or off. Researchers are particularly interested in how these changes happen when brain cells are active, as this might reveal new ways these genetic differences affect brain function and disease.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation, but future clinical applications would target individuals with neuropsychiatric disorders like schizophrenia.
Not a fit: Patients not diagnosed with neuropsychiatric disorders would not directly benefit from this specific line of research.
Why it matters
Potential benefit: If successful, this work could help identify the specific genetic changes and genes responsible for neuropsychiatric disorders, leading to new targets for treatments.
How similar studies have performed: Previous work by this team has already identified regulatory variants affecting chromatin accessibility in human neurons, showing promise for this approach.
Where this research is happening
EVANSTON, UNITED STATES
- ENDEAVOR HEALTH CLINICAL OPERATIONS — EVANSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DUAN, JUBAO — ENDEAVOR HEALTH CLINICAL OPERATIONS
- Study coordinator: DUAN, JUBAO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.