Understanding Genetic Differences in Blood Cells
Structural Variation and Hematological Traits
['FUNDING_R01'] · UNIVERSITY OF WASHINGTON · NIH-11127380
This project looks at tiny genetic differences in blood cells to better understand blood disorders and predict risks for heart, lung, and other health conditions.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WASHINGTON (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-11127380 on ClinicalTrials.gov |
What this research studies
Our blood cells, including red cells, white cells, and platelets, are vital for diagnosing blood disorders and can even signal risks for heart, lung, and other diseases. We know that many blood traits are passed down through families, making them a great way to learn about how genetics influence complex health conditions. This project uses vast amounts of genetic information from large groups of people to find larger genetic changes, called structural variants, that might affect blood cell health. We are also developing better computer tools to identify these variants and confirming their effects using advanced gene-editing techniques in blood cells. Ultimately, this work aims to uncover new biological insights into blood health.
Who could benefit from this research
Good fit: This foundational genetic work does not directly involve patient recruitment but could eventually benefit individuals with inherited blood disorders or those at risk for heart, lung, and blood diseases.
Not a fit: Patients seeking immediate new treatments or direct clinical intervention would not find direct benefit from this basic genetic research.
Why it matters
Potential benefit: If successful, this work could lead to earlier and more accurate diagnoses for blood disorders and better predictions for various heart, lung, and blood disease outcomes.
How similar studies have performed: While some common structural variants are known to affect blood traits, this project aims for a more comprehensive, genome-wide discovery of new variants, building on previous genetic association studies.
Where this research is happening
SEATTLE, UNITED STATES
- UNIVERSITY OF WASHINGTON — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: REINER, ALEXANDER P — UNIVERSITY OF WASHINGTON
- Study coordinator: REINER, ALEXANDER P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.