Understanding genetic differences in bacterial strains
Parallel phenotyping to dissect genetic determinants of bacterial strain diversity
This study is looking at how different genetic types of bacteria behave and respond to treatments, especially for infections caused by Mycobacterium avium, to help find better ways to manage these chronic infections.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-10889085 on NIH RePORTER |
What this research studies
This research investigates how genetic diversity among bacterial strains affects their behavior and response to treatments. By using a novel molecular barcoding technique, researchers can analyze the fitness of multiple bacterial isolates simultaneously in controlled experiments. This approach aims to uncover the genetic factors that contribute to variations in disease progression and treatment outcomes, particularly for infections caused by Mycobacterium avium. The findings could lead to improved strategies for managing chronic bacterial infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from chronic infections caused by Mycobacterium avium.
Not a fit: Patients with bacterial infections not caused by Mycobacterium avium may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments and vaccines for bacterial infections.
How similar studies have performed: Other research has shown success using similar molecular barcoding techniques to study bacterial diversity and treatment responses.
Where this research is happening
Salt Lake City, United States
- University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Carey, Allison — University of Utah
- Study coordinator: Carey, Allison
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.