Understanding genetic differences in bacteria that affect infections
Parallel phenotyping to dissect genetic determinants of bacterial strain diversity
This study is looking at how differences in bacteria genes affect how they behave during infections and respond to treatments, especially for those caused by Mycobacterium avium, to help find better ways to treat patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-11049320 on NIH RePORTER |
What this research studies
This research investigates how genetic diversity among bacterial strains influences their behavior, particularly in relation to infections and treatment responses. By using a novel molecular barcoding technique, the study aims to analyze hundreds of bacterial isolates simultaneously to identify specific genetic factors that affect their virulence and susceptibility to antibiotics. This approach will help in understanding the variability in disease outcomes and treatment effectiveness, particularly for infections caused by Mycobacterium avium. Patients may benefit from insights gained that could lead to improved treatment strategies and public health interventions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with chronic infections caused by Mycobacterium avium or those at risk of such infections.
Not a fit: Patients with infections caused by bacteria other than Mycobacterium avium may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments and vaccines for bacterial infections, particularly those that are difficult to manage.
How similar studies have performed: Other research has shown promise in using genetic profiling to understand bacterial behavior, suggesting that this approach could yield valuable insights.
Where this research is happening
Salt Lake City, United States
- University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Carey, Allison — University of Utah
- Study coordinator: Carey, Allison
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.