Understanding Genetic Differences in Alzheimer's Disease Between Men and Women
Sex-Specific Genetic Drivers of Alzheimer's Disease Endophenotypes
This project explores how genetic factors might cause Alzheimer's disease to affect men and women differently.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-11115614 on NIH RePORTER |
What this research studies
Alzheimer's disease affects more women than men, and it appears to impact their brains and thinking abilities in different ways. This project aims to discover specific genetic factors that contribute to these differences in how the disease develops and progresses in men compared to women. By looking at information from many past studies on aging and Alzheimer's, researchers hope to uncover these unique genetic influences. Understanding these sex-specific genetic pathways could lead to more tailored and effective treatments for everyone living with Alzheimer's.
Who could benefit from this research
Good fit: Patients with late-onset Alzheimer's disease, particularly those interested in how genetics influence the disease differently in men and women, are the focus of this research.
Not a fit: Patients not living with Alzheimer's disease or those not interested in genetic research may not directly benefit from this specific project.
Why it matters
Potential benefit: If successful, this work could lead to more personalized and effective treatments for Alzheimer's disease, specifically designed for men or women.
How similar studies have performed: Previous research has started to identify genetic factors that explain some differences in Alzheimer's between men and women, suggesting this approach has a foundation.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Dumitrescu, Logan C — Vanderbilt University Medical Center
- Study coordinator: Dumitrescu, Logan C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.