Understanding Genetic Differences in Alzheimer's Disease
Multi-omic functional assessment of novel AD variants using high-throughput and single-cell technologies
This project aims to understand how specific genetic variations contribute to Alzheimer's disease by looking closely at individual cells.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-11118794 on NIH RePORTER |
What this research studies
Many small changes in our genes are linked to a higher chance of developing Alzheimer's disease, but we don't fully understand how they work. This project will create a detailed map of gene activity in different types of cells from people with Alzheimer's. Researchers will then use advanced computer methods to pinpoint which genetic changes are most important for the disease. The goal is to uncover the specific ways these genetic differences affect brain cells and lead to Alzheimer's.
Who could benefit from this research
Good fit: This foundational genetic work is not directly recruiting patients for a clinical trial, but future studies stemming from this research may seek individuals with Alzheimer's disease or those at risk.
Not a fit: Patients not interested in contributing biological samples or participating in future genetic-focused research may not directly benefit from this specific grant.
Why it matters
Potential benefit: If successful, this work could reveal new targets for developing treatments that address the genetic roots of Alzheimer's disease.
How similar studies have performed: While the overall approach of identifying genetic risk factors for Alzheimer's has seen success, this project uses novel high-throughput and single-cell technologies to functionally characterize previously unclear genetic variants.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Montine, Thomas J — Stanford University
- Study coordinator: Montine, Thomas J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.