Understanding genetic changes related to age and health in diverse populations
Official title: Discovering and Analyzing Development and Age-Associated CNAs in the All of Us Cohort
Funded at Mayo Clinic Rochester · NIH-10930955 · Data updated 2026-11-12
This study looks at how changes in our genes as we get older might affect our health, especially for conditions like blood cancer and heart disease, and it aims to help people understand how their unique genetics can influence their health risks as they age.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | September 20, 2023 |
| Project end | April 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $145,260 |
| NIH project number | 5R03AG085705-02 |
| Project ID | NIH-10930955 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals from diverse backgrounds who are part of the All of Us cohort and are interested in understanding the genetic aspects of their health as they age.
✕Less likely to help
Patients with no interest in genetic research or those not part of the All of Us cohort may not receive direct benefits from this research.
What this research studies
This research investigates how genetic changes, specifically somatic copy number variations (CNVs), occur as people age and how these changes relate to various health outcomes. By analyzing whole genome sequencing data from the All of Us cohort, researchers will identify and categorize these genetic variations, focusing on their implications for conditions like blood cancer and cardiovascular diseases. Patients may benefit from insights into how their genetic makeup influences their health risks as they age, potentially leading to more personalized healthcare strategies.
Why it matters
Potential benefit: If successful, this research could enhance understanding of genetic factors influencing age-related health risks, leading to improved prevention and treatment strategies for patients.
How similar studies have gone: Previous research has shown promising results in understanding genetic variations and their health implications, making this approach both relevant and potentially impactful.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Abyzov, Alexej — Mayo Clinic Rochester
- Study coordinator: Abyzov, Alexej
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.