Understanding genetic changes in triple-negative breast cancer in African women
Landscape and characterization of promoter mutations driving triple-negative breast cancer
['FUNDING_R21'] · MASSACHUSETTS GENERAL HOSPITAL · NIH-10887645
This study is looking at how certain genetic changes in women of African ancestry might affect triple-negative breast cancer, with the hope of finding new ways to treat it better.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MASSACHUSETTS GENERAL HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10887645 on ClinicalTrials.gov |
What this research studies
This research investigates the genetic and epigenetic factors that contribute to triple-negative breast cancer (TNBC) in women of African ancestry. It focuses on the role of promoter mutations and how these changes may lead to a loss of DNA repair mechanisms, which are critical for the development of targeted therapies. By utilizing a novel sequencing technology to analyze over 3,000 cancer gene promoters, the study aims to identify actionable mutations that could inform treatment options for patients. The goal is to enhance the understanding of TNBC in this population and improve therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are women of African ancestry diagnosed with triple-negative breast cancer.
Not a fit: Patients with other subtypes of breast cancer or those not of African ancestry may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatment options for women with triple-negative breast cancer by identifying specific genetic alterations that can be targeted.
How similar studies have performed: While research on triple-negative breast cancer is ongoing, this specific focus on promoter mutations in women of African ancestry is relatively novel and has not been extensively studied.
Where this research is happening
BOSTON, UNITED STATES
- MASSACHUSETTS GENERAL HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RHEINBAY, ESTHER — MASSACHUSETTS GENERAL HOSPITAL
- Study coordinator: RHEINBAY, ESTHER
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.