Understanding Genetic Changes in Oral Precancerous Growths
Genetic Alterations That Confer High Risk to Oral Premalignant Lesions
This research looks at specific genetic changes in precancerous mouth sores to find better ways to stop them from turning into oral cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arizona NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project ID | NIH-11098592 on NIH RePORTER |
What this research studies
Oral squamous cell carcinoma is a common cancer, and about 30% of precancerous mouth sores can develop into it, often linked to factors like tobacco. Our goal is to pinpoint the genetic changes that make these sores high-risk for progressing to cancer. We also want to learn how these genetic changes affect how precancerous sores respond to treatments designed to prevent cancer. This work uses special mouse models to understand how early genetic changes in genes like p53 and CDKN2A might create an environment in the mouth that encourages cancer growth.
Who could benefit from this research
Good fit: Patients with oral premalignant lesions, especially those with a history of tobacco use, are the focus of this research.
Not a fit: Patients who already have advanced oral cancer may not directly benefit from this early-stage prevention research.
Why it matters
Potential benefit: If successful, this work could lead to new and more effective ways to prevent precancerous mouth sores from developing into oral cancer.
How similar studies have performed: Previous attempts with different chemopreventive agents for oral precancerous lesions have not been successful, suggesting this approach exploring genetic drivers and immune responses is novel.
Where this research is happening
Tucson, United States
- University of Arizona — Tucson, United States (Active)
Researchers
- Principal investigator: Caulin, Carlos — University of Arizona
- Study coordinator: Caulin, Carlos
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.