Understanding genetic changes in normal tissues and their role in health and disease
Comprehensive Somatic Variant Characterization at the HGSC
['FUNDING_OTHER'] · BAYLOR COLLEGE OF MEDICINE · NIH-11083082
This study is looking at genetic changes in normal tissues to understand how they might affect our health and contribute to aging and cancer, and it could help improve how we diagnose and treat these conditions in the future.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BAYLOR COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-11083082 on ClinicalTrials.gov |
What this research studies
This research aims to explore somatic mutations, which are genetic changes that occur in normal tissues rather than just in cancerous cells. By analyzing 750 tissue samples from 150 individuals, the study will utilize advanced sequencing techniques to identify and characterize these mutations. The goal is to build a comprehensive understanding of how these genetic variations contribute to health and disease, potentially leading to new insights into aging and cancer biology. Patients may benefit from improved diagnostic and therapeutic strategies based on this knowledge.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a diverse range of normal tissue samples, particularly those interested in the genetic aspects of aging and disease.
Not a fit: Patients with no available tissue samples or those with exclusively pathogenic mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for various diseases, including cancer.
How similar studies have performed: Previous research has shown promise in characterizing somatic mutations, but this approach aims to expand knowledge in a novel way by focusing on normal tissues.
Where this research is happening
HOUSTON, UNITED STATES
- BAYLOR COLLEGE OF MEDICINE — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GIBBS, RICHARD A — BAYLOR COLLEGE OF MEDICINE
- Study coordinator: GIBBS, RICHARD A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers