Understanding genetic changes in malaria-causing parasites
The evolution of copy number variations in the AT-rich Plasmodium genome
This study is looking at how changes in the genes of the malaria parasite can help it resist treatments, so we can better understand how it survives and adapts in people with malaria.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-11074103 on NIH RePORTER |
What this research studies
This research investigates how changes in the genetic material of the malaria parasite, Plasmodium falciparum, affect its ability to adapt and develop resistance to treatments. By examining specific regions of the parasite's genome that are rich in adenine and thymine (A/T), the study aims to uncover the mechanisms behind these genetic variations. The researchers will use advanced techniques to analyze the genome of different Plasmodium species, focusing on how these variations contribute to the parasite's survival and adaptability in human hosts.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals infected with malaria, particularly those experiencing treatment-resistant cases.
Not a fit: Patients who do not have malaria or are not affected by drug-resistant strains of the parasite may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for combating malaria and reducing drug resistance in patients.
How similar studies have performed: Previous research has shown that understanding genetic variations in pathogens can lead to significant advancements in treatment strategies, indicating potential success for this approach.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Guler, Jennifer Lynn — University of Virginia
- Study coordinator: Guler, Jennifer Lynn
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.