Understanding genetic changes in high-risk ovarian cancer
Exploiting markers of genomic instability in high-risk pre-invasive ovarian cancer
['FUNDING_R01'] · SLOAN-KETTERING INST CAN RESEARCH · NIH-11083078
This study is looking at how certain genetic changes happen early on in high-grade serous ovarian cancer, especially for those with inherited BRCA1 or BRCA2 mutations, to find markers that could help predict if a pre-cancer condition will turn into invasive cancer, ultimately aiming to improve treatment options for patients at higher risk.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SLOAN-KETTERING INST CAN RESEARCH (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11083078 on ClinicalTrials.gov |
What this research studies
This research investigates the early genetic changes that occur in high-grade serous ovarian cancer (HGSC), particularly in patients at increased risk due to inherited BRCA1/BRCA2 mutations. The study focuses on identifying biomarkers of genomic instability, which may help predict the progression from pre-invasive conditions to invasive cancer. By analyzing patient samples, researchers aim to quantify specific markers associated with chromosomal instability, potentially leading to improved treatment strategies for high-risk individuals. The goal is to enhance therapeutic decisions and outcomes for patients who have undergone preventive surgeries.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with BRCA1 or BRCA2 mutations who are at high risk for ovarian cancer.
Not a fit: Patients without genetic predispositions to ovarian cancer or those who do not carry BRCA1/BRCA2 mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better monitoring and treatment options for patients at high risk of developing ovarian cancer.
How similar studies have performed: Previous research has shown promising results in identifying biomarkers for cancer progression, suggesting that this approach may yield valuable insights.
Where this research is happening
NEW YORK, UNITED STATES
- SLOAN-KETTERING INST CAN RESEARCH — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHAH, SOHRAB P — SLOAN-KETTERING INST CAN RESEARCH
- Study coordinator: SHAH, SOHRAB P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.