Understanding genetic changes in gliomas and their impact on patient outcomes
Characterizing germline and somatic alterations by glioma subtypes and clinical outcome
This study is looking at how changes in genes might affect different kinds of brain tumors called gliomas and how these changes can influence how well patients do, so it’s aimed at helping glioma patients understand their condition better and improve treatment options.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-10611422 on NIH RePORTER |
What this research studies
This research investigates the genetic alterations associated with different types of gliomas, a type of brain tumor, and how these changes relate to patient outcomes. By analyzing tumor tissue and germline DNA from over 1,350 glioma patients, the study aims to uncover the connections between inherited genetic factors and the development of glioma subtypes. The research utilizes advanced genetic profiling techniques and detailed clinical data to provide insights into how these tumors evolve and respond to treatment. This comprehensive approach seeks to fill gaps in current knowledge about glioma biology and improve treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with gliomas, particularly those who are 21 years or older and have available tumor tissue and germline DNA.
Not a fit: Patients with gliomas who do not have accessible tumor tissue or germline DNA may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more personalized treatment options for glioma patients based on their unique genetic profiles.
How similar studies have performed: Previous research has shown promising results in understanding glioma genetics, but this study aims to provide deeper insights into the specific interactions between germline and somatic alterations, making it a novel approach.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Bondy, Melissa L. — Stanford University
- Study coordinator: Bondy, Melissa L.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.