Understanding genetic changes in certain cancers
Genomic Biology of the Tandem Duplicator Phenotype in Mouse and Human Cancers
['FUNDING_R01'] · JACKSON LABORATORY · NIH-10990509
This study is looking into a genetic change that happens in some types of breast, ovarian, and endometrial cancers to help us understand how it affects cancer growth, which could lead to better treatments for patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JACKSON LABORATORY (nih funded) |
| Locations | 1 site (BAR HARBOR, UNITED STATES) |
| Trial ID | NIH-10990509 on ClinicalTrials.gov |
What this research studies
This research investigates a specific type of genetic instability known as the Tandem Duplicator Phenotype (TDP), which is prevalent in about 50% of triple negative breast, ovarian, and endometrial cancers. By using a combination of computational analyses and laboratory experiments, the researchers aim to uncover the mechanisms that lead to the formation of these genetic changes and how they influence cancer development. The study will involve both mouse models and human cancer data to explore the role of specific genes, such as Trp53 and Brca1, in the emergence of TDPs. Patients may benefit from a better understanding of their cancer's genetic profile and potential new treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with triple negative breast cancer, ovarian cancer, or endometrial cancer.
Not a fit: Patients with cancers not associated with the Tandem Duplicator Phenotype may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options and personalized therapies for patients with specific types of cancer.
How similar studies have performed: Previous research has shown promising results in understanding genetic instability in cancers, suggesting that this approach could yield valuable insights.
Where this research is happening
BAR HARBOR, UNITED STATES
- JACKSON LABORATORY — BAR HARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LIU, EDISON TAK-BUN — JACKSON LABORATORY
- Study coordinator: LIU, EDISON TAK-BUN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: anti-cancer research, anti-cancer therapy