Understanding Genetic Changes in Cells Using Yeast
High-throughput experimental determination and computational prediction of variant effects in yeast
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA LOS ANGELES · NIH-11158712
This project helps us understand how tiny changes in DNA affect living cells, using yeast as a model to learn more about human health.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA LOS ANGELES (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-11158712 on ClinicalTrials.gov |
What this research studies
Our bodies, like all living things, are made of cells, and the instructions for these cells are in our DNA. This project uses baker's yeast, a simple organism, to explore how small changes in its DNA can lead to different traits. Because yeast shares many basic biological processes with humans, what we learn here can help us understand human diseases better. We use advanced tools like CRISPR gene editing and single-cell sequencing to study these genetic changes on a very large scale.
Who could benefit from this research
Good fit: Patients who may benefit from future advancements in understanding genetic diseases and improving diagnostic accuracy could follow this research.
Not a fit: Patients seeking immediate treatment options or direct clinical interventions would not find direct benefit from this foundational laboratory research.
Why it matters
Potential benefit: If successful, this work could lead to better ways to understand genetic conditions in humans and improve the accuracy of patient diagnoses based on their DNA.
How similar studies have performed: This project builds on existing knowledge of yeast genetics but introduces novel, large-scale approaches using advanced technologies like single-cell sequencing and CRISPR for genetic mapping.
Where this research is happening
LOS ANGELES, UNITED STATES
- UNIVERSITY OF CALIFORNIA LOS ANGELES — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KRUGLYAK, LEONID — UNIVERSITY OF CALIFORNIA LOS ANGELES
- Study coordinator: KRUGLYAK, LEONID
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.